Prognostic alternative splicing regulatory network of RBM25 in hepatocellular carcinoma

RNA-binding motif protein 25 (RBM25) is a poorly characterized RNA-binding protein that is involved in several biological processes and regulates the proliferation and metastasis of tumor cells. The regulatory role of RBM25 in hepatocellular carcinoma (HCC) is unknown. Here, RBM25 expression and out...

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Veröffentlicht in:	Bioengineered 2021-01, Vol.12 (1), p.1202-1211
Hauptverfasser:	Zhang, Yong-Fa, Wang, Yi-Xiu, Zhang, Ning, Lin, Zhen-Hai, Wang, Long-Rong, Feng, Yun, Pan, Qi, Wang, Lu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Alternative Splicing - genetics Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Line, Tumor Chromosomal Proteins, Non-Histone - genetics Chromosomal Proteins, Non-Histone - metabolism Female Gene Expression Regulation, Neoplastic Gene Regulatory Networks hepatocellular carcinoma Humans Liver Neoplasms - genetics Liver Neoplasms - pathology Male Middle Aged Nuclear Proteins - genetics Nuclear Proteins - metabolism overall survival Prognosis RBM25 regulatory network Research Paper
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Zusammenfassung:	RNA-binding motif protein 25 (RBM25) is a poorly characterized RNA-binding protein that is involved in several biological processes and regulates the proliferation and metastasis of tumor cells. The regulatory role of RBM25 in hepatocellular carcinoma (HCC) is unknown. Here, RBM25 expression and outcomes in HCC patients were evaluated using The Cancer Genome Atlas database. RBM25 was overexpressed in HCC patients compared with the healthy group. The high expression of RBM25 in tumor tissues was significantly related to poor overall survival (P
ISSN:	2165-5979 2165-5987
DOI:	10.1080/21655979.2021.1908812