Effect of CMNa combined with radiotherapy on the tumor immune microenvironment of mouse cervical cancer cell transplantation tumor model

In this study, we construct a subcutaneous tumor mice model of U14 cells, observe the tumor growth, and detect the expression of Foxp3 and VISTA in cervical cancer tissues and adjacent tissues during CMNa-enhancing radiotherapy.From the 15th day, compared with the control group, the tumor volume cha...

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Veröffentlicht in:	Bioengineered 2021-01, Vol.12 (1), p.1066-1077
Hauptverfasser:	Li, Li, Shi, Weiqiang, Zhou, Juying
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals cervical cancer Combined Modality Therapy Female Forkhead transcription factor (Foxp3) Forkhead Transcription Factors - metabolism glycididazole sodium (CMNa) Imidazoles - pharmacology Imidazoles - therapeutic use immune microenvironment Membrane Proteins - metabolism Mice Mice, Inbred C57BL Neoplasm Transplantation Research Paper T cell activation inhibitor immunoglobulin variable domain (VISTA) Tumor Burden - drug effects Uterine Cervical Neoplasms - drug therapy Uterine Cervical Neoplasms - radiotherapy
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Beschreibung
Zusammenfassung:	In this study, we construct a subcutaneous tumor mice model of U14 cells, observe the tumor growth, and detect the expression of Foxp3 and VISTA in cervical cancer tissues and adjacent tissues during CMNa-enhancing radiotherapy.From the 15th day, compared with the control group, the tumor volume changes in each treatment group were significant (P
ISSN:	2165-5979 2165-5987
DOI:	10.1080/21655979.2021.1899532