Palladium-Catalyzed Linear Hydrothiocarbonylation of Unactivated Terminal Alkenes: Synthesis of Aliphatic Thioesters

Palladium-Catalyzed Linear Hydrothiocarbonylation of Unactivated Terminal Alkenes: Synthesis of Aliphatic Thioesters

A Pd-catalyzed hydrothiocarbonylation of unactivated terminal alkenes is presented. According to this protocol, aliphatic thioesters were synthesized with exclusive linear selectivity under mild reaction conditions. Good to excellent yields (up to 91% yield), broad substrate scope, broad functional...

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Veröffentlicht in:Organic letters 2021-04, Vol.23 (7), p.2482-2487
Hauptverfasser: Yu, Wangzhi, Han, Jian, Fang, Dongmei, Wang, Min, Liao, Jian
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creator Yu, Wangzhi
Han, Jian
Fang, Dongmei
Wang, Min
Liao, Jian
description A Pd-catalyzed hydrothiocarbonylation of unactivated terminal alkenes is presented. According to this protocol, aliphatic thioesters were synthesized with exclusive linear selectivity under mild reaction conditions. Good to excellent yields (up to 91% yield), broad substrate scope, broad functional group tolerance, and utility of the method demonstrated the advantages of this protocol.
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subjects Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
title Palladium-Catalyzed Linear Hydrothiocarbonylation of Unactivated Terminal Alkenes: Synthesis of Aliphatic Thioesters
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