Palladium-Catalyzed Linear Hydrothiocarbonylation of Unactivated Terminal Alkenes: Synthesis of Aliphatic Thioesters

Palladium-Catalyzed Linear Hydrothiocarbonylation of Unactivated Terminal Alkenes: Synthesis of Aliphatic Thioesters

A Pd-catalyzed hydrothiocarbonylation of unactivated terminal alkenes is presented. According to this protocol, aliphatic thioesters were synthesized with exclusive linear selectivity under mild reaction conditions. Good to excellent yields (up to 91% yield), broad substrate scope, broad functional...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Organic letters 2021-04, Vol.23 (7), p.2482-2487
Hauptverfasser: Yu, Wangzhi, Han, Jian, Fang, Dongmei, Wang, Min, Liao, Jian
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A Pd-catalyzed hydrothiocarbonylation of unactivated terminal alkenes is presented. According to this protocol, aliphatic thioesters were synthesized with exclusive linear selectivity under mild reaction conditions. Good to excellent yields (up to 91% yield), broad substrate scope, broad functional group tolerance, and utility of the method demonstrated the advantages of this protocol.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.1c00406