Drug interaction between letermovir and voriconazole after allogeneic hematopoietic cell transplantation

Letermovir has been approved for the prevention of cytomegalovirus (CMV) infection after allogeneic hematopoietic stem cell transplantation (HCT). Letermovir is a cytochrome P450 (CYP) 2C19 inducer. Voriconazole, which is a broad-spectrum triazole antifungal agent, is mainly metabolized by CYP2C19....

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Veröffentlicht in:	International journal of hematology 2021-06, Vol.113 (6), p.872-876
Hauptverfasser:	Nakashima, Toshihisa, Inamoto, Yoshihiro, Fukushi, Yayoi, Doke, Yoshiyuki, Hashimoto, Hironobu, Fukuda, Takahiro, Yamaguchi, Masakazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Antifungal agents Antiviral drugs Cytochrome Cytochrome P450 Cytochromes P450 Cytomegalovirus Drug interaction Drug interactions Fungicides Hematology Hematopoietic stem cells Infections Life Sciences & Biomedicine Medicine Medicine & Public Health Oncology Original Article Prevention Science & Technology Stem cell transplantation Stem cells Therapeutic drug monitoring Transplantation Voriconazole
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Zusammenfassung:	Letermovir has been approved for the prevention of cytomegalovirus (CMV) infection after allogeneic hematopoietic stem cell transplantation (HCT). Letermovir is a cytochrome P450 (CYP) 2C19 inducer. Voriconazole, which is a broad-spectrum triazole antifungal agent, is mainly metabolized by CYP2C19. Thus, voriconazole trough concentration may decrease due to the drug interaction between voriconazole and letermovir. This study aimed to clarify the effects of letermovir on voriconazole trough concentration in allogeneic HCT recipients. We retrospectively examined voriconazole trough concentration in 24 allogeneic HCT recipients who had letermovir for prevention of CMV infection. The median voriconazole C/D ratios significantly decreased after starting letermovir from 0.25 L/kg to 0.11 L/kg ( p
ISSN:	0925-5710 1865-3774
DOI:	10.1007/s12185-021-03105-x