Urine LAM Testing in Advanced HIV Positive Adults in a Trial of Empiric TB Therapy

Urine LAM Testing in Advanced HIV Positive Adults in a Trial of Empiric TB Therapy

The urine lipoarabinomannan (LAM) antigen test is a TB diagnostic test with highest sensitivity in individuals with advanced HIV. Its role in TB diagnostic algorithms for HIV positive outpatients remains unclear. ACTG A5274 trial demonstrated that empiric TB therapy did not improve 24-week survival...

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Veröffentlicht in:Clinical infectious diseases 2021-02
Hauptverfasser: Matoga, Mitch M, Bisson, Gregory P, Gupta, Amita, Miyahara, Sachiko, Sun, Xin, Fry, Carrie, Manabe, Yukari C, Kumwenda, Johnstone, Cecilia, Kanyama, Nyirenda, Mulinda, Ngongondo, McNeil, Mbewe, Abineli, Lagat, David, Wallis, Carole, Mugerwa, Henry, Hosseinipour, Mina C
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Sprache:eng
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Zusammenfassung:The urine lipoarabinomannan (LAM) antigen test is a TB diagnostic test with highest sensitivity in individuals with advanced HIV. Its role in TB diagnostic algorithms for HIV positive outpatients remains unclear. ACTG A5274 trial demonstrated that empiric TB therapy did not improve 24-week survival compared to isoniazid preventive therapy (IPT) in TB screen negative HIV positive adults initiating ART with CD4 counts
ISSN:1537-6591