Convalescent Plasma Antibody Levels and the Risk of Death from Covid-19

Among more than 3000 hospitalized patients with Covid-19, recipients of high-titer convalescent plasma had a lower mortality at 30 days than recipients of low-titer plasma. The effect of high-titer plasma was greatest in the subgroup of patients who were not receiving mechanical ventilation.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2021-03, Vol.384 (11), p.1015-1027
Hauptverfasser:	Joyner, Michael J, Carter, Rickey E, Senefeld, Jonathon W, Klassen, Stephen A, Mills, John R, Johnson, Patrick W, Theel, Elitza S, Wiggins, Chad C, Bruno, Katelyn A, Klompas, Allan M, Lesser, Elizabeth R, Kunze, Katie L, Sexton, Matthew A, Diaz Soto, Juan C, Baker, Sarah E, Shepherd, John R.A, van Helmond, Noud, Verdun, Nicole C, Marks, Peter, van Buskirk, Camille M, Winters, Jeffrey L, Stubbs, James R, Rea, Robert F, Hodge, David O, Herasevich, Vitaly, Whelan, Emily R, Clayburn, Andrew J, Larson, Kathryn F, Ripoll, Juan G, Andersen, Kylie J, Buras, Matthew R, Vogt, Matthew N.P, Dennis, Joshua J, Regimbal, Riley J, Bauer, Philippe R, Blair, Janis E, Paneth, Nigel S, Fairweather, DeLisa, Wright, R. Scott, Casadevall, Arturo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Algorithms Antibodies Antibodies, Viral - blood Coronaviridae Coronaviruses COVID-19 COVID-19 - immunology COVID-19 - mortality COVID-19 - therapy COVID-19 Serotherapy Death Decision trees Female General & Internal Medicine Generalized linear models Hospitalization Humans Hypotheses Immunization, Passive Immunoassay Immunoglobulin G Immunoglobulin G - blood Laboratories Life Sciences & Biomedicine Male Mechanical ventilation Medicine, General & Internal Middle Aged Mortality Pandemics Patients Plasma Proteins Registries Respiration, Artificial Retrospective Studies Risk Factors Sample size SARS-CoV-2 - immunology Science & Technology Severe acute respiratory syndrome coronavirus 2 Statistical analysis Time-to-Treatment United States - epidemiology Young Adult
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Beschreibung
Zusammenfassung:	Among more than 3000 hospitalized patients with Covid-19, recipients of high-titer convalescent plasma had a lower mortality at 30 days than recipients of low-titer plasma. The effect of high-titer plasma was greatest in the subgroup of patients who were not receiving mechanical ventilation.
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMoa2031893