FUNCTIONAL RESULTS` ANALYSIS OF L-PRP APPLICATION FOR PATIENTS WITH MENISCUS INJURIES OF THE KNEE JOINT

Today, modern medical practice proposes to abandon surgical methods for treating meniscus injuries and allows the use of more effective and modern technologies, including regenerative injection techniques. The aim of the study was to evaluate the effectiveness of L-PRP injections in the knee meniscus injury. The study was conducted on the basis of the Center for tissue and cell therapy of the State Institution «ITO NAMS of Ukraine» during 2017-2020. The study involved 120 patients who were divided into 2 groups: for group 1 (n=58), the course of treatment consisted of 3 intra-articular injections of autologous PRP; for group 2 (n=62) - the course of treatment was 4-6 injections. The functional state of the patients was assessed based on the VAS, WOMAC, and the Oxford Knee Score (OKS) scale at the time of the visit, after 3 months, 12 months. and 2 years after completion of the course of injection therapy. After using regenerative injections, after 3 months there was an improvement on the WOMAC questionnaire in both groups. However, upon examination after 2 years, a positive result remained only in group 2 ((28,9±3,6 points)), in group 1, negative dynamics was observed (53,6±4,2 points), despite the fact that the result after 2 years was still better than before the injection therapy. According to the results of the VAS survey, the patients showed positive dynamics, which persisted up to 12 months. However, in group1 after 12 months. an increase in pain syndrome was observed (up to 3,3±0,7 points), which persisted throughout the observation period (4,2±0,6 points). In group 2, positive dynamics persisted throughout the observation period (after 2 years, 1,5±0,5 points). A similar trend was observed using the Oxford knee score at all stages of observation. According to our observations, a course of treatment of 4-6 injections of autologous L-PRP has a cumulative effect and improves the quality of life of patients with traumatic injuries of the meniscus of the knee joint for a longer period (up to 2 years) compared to a course of 3 injections (up to 1 year).