WNT: an unexpected tumor suppressor in medulloblastoma

WNT: an unexpected tumor suppressor in medulloblastoma

Medulloblastoma (MB) represents the most common malignant pediatric brain tumor and is defined by four molecular subgroups with WNT MB having the most favorable prognosis. Our work provides a rational therapeutic option in which the protective effects of WNT-driven MBs may be augmented in Group 3 an...

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Veröffentlicht in:Molecular & cellular oncology 2020-11, Vol.7 (6), p.1834903-1834903
Hauptverfasser: Manoranjan, Branavan, Adile, Ashley A., Venugopal, Chitra, Singh, Sheila K.
Format: Artikel
Sprache:eng
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beta-catenin
brain tumor-initiating cell
Medulloblastoma
WNT
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Zusammenfassung:Medulloblastoma (MB) represents the most common malignant pediatric brain tumor and is defined by four molecular subgroups with WNT MB having the most favorable prognosis. Our work provides a rational therapeutic option in which the protective effects of WNT-driven MBs may be augmented in Group 3 and 4 MB.
ISSN:2372-3556
2372-3556
DOI:10.1080/23723556.2020.1834903