Aromatic Ring Substituted Aaptamine Analogues as Potential Cytotoxic Agents against Extranodal Natural Killer/T-Cell Lymphoma

Aromatic Ring Substituted Aaptamine Analogues as Potential Cytotoxic Agents against Extranodal Natural Killer/T-Cell Lymphoma

A chemical modification study was conducted on the marine natural product aaptamine (1), isolated from the marine sponge Aaptos aaptos. Thirty new derivatives substituted by various aromatic rings at the 3- and 7-positions of aaptamine were prepared by bromination, followed by the Suzuki coupling re...

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Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 2020-12, Vol.83 (12), p.3758-3763
Hauptverfasser: Yang, Fan, Gao, Yuan, Chang, Yung-Ting, Zou, Yike, Houk, K. N, Lu, Jing-Rong, He, Jing, Tang, Wei-Zhuo, Liao, Hong-Ze, Han, Hua, Lin, Hou-Wen
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry, Medicinal
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Plant Sciences
Science & Technology
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Zusammenfassung:A chemical modification study was conducted on the marine natural product aaptamine (1), isolated from the marine sponge Aaptos aaptos. Thirty new derivatives substituted by various aromatic rings at the 3- and 7-positions of aaptamine were prepared by bromination, followed by the Suzuki coupling reaction. Sixteen compounds displayed cytotoxicities to four cancer cell lines (IC50 < 10 μM). In particular, compound 5i demonstrated a significant antiproliferative effect on the extranodal natural killer/T-cell lymphoma (ENKT) cell line SNK-6 with an IC50 value of 0.6 μM. Additionally, compound 5i showed cytotoxicities to multiple lymphoma cell lines, including Ramos, Raji, WSU-DLCL2, and SU-DHL-4 cells.
ISSN:0163-3864
1520-6025
DOI:10.1021/acs.jnatprod.0c00769