A COF-based anti-interference nanoplatform for intracellular nucleic acid imaging

A COF-based anti-interference nanoplatform for intracellular nucleic acid imaging

We demonstrate here that a porphyrin covalent organic framework-based nanoplatform could effectively avoid the interference of proteins and biothiols and result in high-fidelity signals in intracellular mRNA imaging. A porphyrin covalent organic framework-based nanoplatform was demonstrated. The nan...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2020-11, Vol.56 (91), p.14267-1427
Hauptverfasser: Gao, Peng, Wang, Mengzhen, Wan, Xiuyan, Liu, Xiaohan, Pan, Wei, Li, Na, Tang, Bo
Format: Artikel
Sprache:eng
Schlagworte:
Cell Line
Chemistry
Chemistry, Multidisciplinary
Humans
Interference
Metal-Organic Frameworks - chemistry
Optical Imaging
Physical Sciences
Porphyrins
Porphyrins - chemistry
RNA, Messenger - analysis
RNA, Messenger - genetics
Science & Technology
Thymidine Kinase - genetics
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:We demonstrate here that a porphyrin covalent organic framework-based nanoplatform could effectively avoid the interference of proteins and biothiols and result in high-fidelity signals in intracellular mRNA imaging. A porphyrin covalent organic framework-based nanoplatform was demonstrated. The nanoplatform could effectively avoid the interference of proteins and biothiols and realize high-fidelity mRNA imaging in living cells.
ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc05527a