Neuromodulatory effect of curcumin on catecholamine systems and inflammatory cytokines in ovariectomized female rats

Anti‐inflammatory products may represent the future for depressive disorder therapies. Curcumin (CUR) is a polyphenol and an active component of the turmeric plant Curcuma longa. The aim of this study was to investigate the impact of CUR, as a natural anti‐inflammatory agent, on neuro‐inflammation related to depression and compare it with the effects of fluoxetine (FLX) and estradiol (E2) in ovariectomized (OVX) rats. The experimental animals were divided into the following five treatment groups (n = 10): sham‐operated, OVX, OVX‐E2 (100 μg/kg, im, every other day), OVX‐FLX (20 mg/kg, ip, daily), and OVX‐CUR (100 mg/kg, po, daily). The results indicated that CUR improved the animals’ performances in the open field test and modulated dopamine (DA) and norepinephrine levels in several brain regions compared with the OVX group. CUR resulted in the down‐regulation of monoamine oxidase b and up‐regulation of tyrosine hydroxylase, as well asDA receptor mRNA in the limbic region. In addition, CUR significantly attenuated the production of serum corticosterone hormone, tumour necrosis factor‐alpha, interleukin‐β1, interleukin‐6, and nitric oxide in the limbic system. Furthermore, CUR normalized malondialdehyde levels and led to a significant upsurge in total antioxidant capacity, compared with the OVX group. Consequently, CUR, besides being harmless, was efficient against inflammation and oxidative–nitrosative stress, showing a greater effect on DA receptor expression than FLX and E2 in OVX rats. The current study was designed to investigate the potential impact of curcumin (CUR), relative to fluoxetine (FLX) and estradiol (E2), on inflammation related to depression in brain of ovariectomized (OVX) rats.