Potential Functions of Plasma Prorenin; Regional Activation and Tissue Extraction

The fate of circulating inactive prorenin was examined in patients and volunteers. Prorenin was activated either by acid-dialysis with warming at pH 3.3 or with trypsin. The results were similar but omission of warming reduced the value by 13%. In 6 volunteers, 20 min forearm venous occlusion raised...

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Veröffentlicht in:Clinical and experimental hypertension (1993) 1987, Vol.A9 (8-9), p.1415-1434
Hauptverfasser: Thatcher, R. L., Butty, J. S., Whitworth, J. A., Hunt, V. D. U., Shaw, P. F., Skinner, S. L., Horowitz, J. D.
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Sprache:eng
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Zusammenfassung:The fate of circulating inactive prorenin was examined in patients and volunteers. Prorenin was activated either by acid-dialysis with warming at pH 3.3 or with trypsin. The results were similar but omission of warming reduced the value by 13%. In 6 volunteers, 20 min forearm venous occlusion raised regional total (T) and inactive (I) plasma renin concentration (PRC) by 51% and 48% without change of active (A) renin. During intense foream exercise the ratio APRC:IPRC did not change in muscle or skin venous blood. Body anaerobic exercise increased APRC 3.7-fold without change in IPRC. These procedures activate plasminogen but are without effect on prorenin. In 18 patient with stable angina, TPRC was lower in coronary sinus than arterial blood (p
ISSN:1064-1963
0730-0077
1525-6006
DOI:10.3109/10641968709158993