CLINICAL STUDIES OF BRL 28500 (CLAVULANIC ACID/TICARCILLIN) IN THE TREATMENT OF INTRAPERITONEAL INFECTIONS AND BILIARY TRACT INFECTIONS

(TIPC) plus 1 part clavulanic acid (CVA). BRL 28500 was administered at doses of 1.6 g or 3.2 g b.i.d., generally for 10 days by drip infusion to patients with intraperitoneal infections or biliary tract infections. Drug concentrations in the ascites were determined. A total of 76 cases was treated...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Japanese journal of antibiotics 1987/04/25, Vol.40(4), pp.759-811
Hauptverfasser: SAKAI, KATSUJI, UEDA, TAKAMI, UCHINO, JUNICHI, HAYASAKA, AKIRA, SHIRAMATSU, KOJI, NAGAMACHI, YUKIO, SHODA, YUICHI, OKUI, KATSUJI, HAYATA, YOSHIHIRO, WATANABE, HIROMU, YAMAGUCHI, SUSUMU, OKAMURA, RYUICHIRO, SAITO, TOSHIAKI, YOKOYAMA, ISAO, DOHI, KIYOHIKO, FUKUDA, YASUHIKO, DEGUCHI, KOICHI
Format: Artikel
Sprache:jpn
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:(TIPC) plus 1 part clavulanic acid (CVA). BRL 28500 was administered at doses of 1.6 g or 3.2 g b.i.d., generally for 10 days by drip infusion to patients with intraperitoneal infections or biliary tract infections. Drug concentrations in the ascites were determined. A total of 76 cases was treated with BRL 28500. These cases included 49 intraperitoneal infections (suppurative peritonitis 29, postoperative peritonitis 20) and 18 biliary tract infections (cholecystitis 5, cholangitis 13). Nine cases were excluded from evaluation according to the committee's assessment. The clinical improvement as assessed by surgeons in charge increased with the duration of continued treatment and efficacies were assessed as 57.1% on day 5, 63.0% on day 7 and 77.8% on day 10 in intraperitoneal infections. Corresponding results in biliary tract infections were 38.9%, 40.0% and 42.9%, respectively. From these results it is clear that the degree of improvement is related to the duration of treatment. The clinical usefulness as assessed by surgeons in charge of the study was 63.8% in intraperitoneal infections (suppurativeperitonitis75.0%, postoperative peritonitis 47.4%) and 58.8% in biliary tract infections (cholecystitis 100%, cholangitis 41.7%). The overall rate of usefulness was 62.5%. The clinical efficacy rates as assessed by the committee were 81.6% in intraperitoneal infections (suppurative peritonitis 93.1%, postoperative peritonitis 65.0%) and 66.7% in biliary tract infections (cholecystitis 100%, cholangitis 53.8%). In cases where causative organisms were isolated, the efficacies were 92.9% in suppurative peritonitis, 58.8% in postoperative peritonitis, 50.0% in cholangitis and overall, 69.2%. In cases from which TIPC-resistant organisms were isolated, the overall efficacy rate was 65.4% (suppurative peritonitis 88.9%, postoperative peritonitis 58.3% and cholangitis 40.0%). Regarding bacteriological effect as assessed by the committee, the eradication rate was 76.9% in intraperitoneal infections and 40.0% in biliary tract infections (71.0% overall). In cases from whom ticarcillin-resistant organisms were isolated the corresponding rates were 68.4% and 33.3%respectively,(63.6% overall). In 4 patients with peritonitis drug levels in the ascites were determined following adminis-tration of BRL 28500 by drip infusion. Good levels of both TIPC and CVA were detected 1 to 3. 5 hours after administration. Considering side effects, mild nausea and vomiting were observed in 1
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.40.759