Role of thymidine in biochemical modulation: a review

The role of thymidine in the treatment of cancer has been under clinical investigation for nearly a decade. Clinical trials have demonstrated that it lacks antitumor activity in its own right. In this review, the mechanism of action and rationale for the use of thymidine as a biochemical modulator o...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1987-08, Vol.47 (15), p.3911-3919
Hauptverfasser:	O'DWYER, P. J, KING, S. A, HOTH, D. F, LEYLAND-JONES, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimetabolites, Antineoplastic - administration & dosage Antimetabolites, Antineoplastic - metabolism Antimetabolites, Antineoplastic - pharmacology Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - pharmacology Antineoplastic Combined Chemotherapy Protocols - therapeutic use Aspartic Acid - administration & dosage Aspartic Acid - analogs & derivatives Aspartic Acid - pharmacology Biological and medical sciences Cytarabine - administration & dosage Cytarabine - metabolism Deoxycytidine Kinase - antagonists & inhibitors DNA Replication - drug effects DNA, Neoplasm - biosynthesis Drug Evaluation Drug Synergism Fluorouracil - administration & dosage Fluorouracil - metabolism Folic Acid Antagonists General aspects Humans Interphase - drug effects Kinetics Leukemia - drug therapy Medical sciences Methotrexate - administration & dosage Methotrexate - pharmacology Mice Neoplasms - drug therapy Neoplasms - metabolism Neoplasms, Experimental - drug therapy Neoplasms, Experimental - metabolism Nucleic Acid Synthesis Inhibitors Nucleotides - metabolism Pharmacology. Drug treatments Phosphonoacetic Acid - administration & dosage Phosphonoacetic Acid - analogs & derivatives Phosphonoacetic Acid - pharmacology RNA, Neoplasm - biosynthesis Species Specificity Thymidine - administration & dosage Thymidine - adverse effects Thymidine - metabolism Thymidine - pharmacology
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Zusammenfassung:	The role of thymidine in the treatment of cancer has been under clinical investigation for nearly a decade. Clinical trials have demonstrated that it lacks antitumor activity in its own right. In this review, the mechanism of action and rationale for the use of thymidine as a biochemical modulator of standard agents such as 5-fluorouracil, 1-beta-D-arabinofuranosylcytosine, and methotrexate are summarized. With this background, the clinical trials which have been conducted with thymidine, either alone or in combination, are described. We suggest a number of further studies of the role of thymidine in the biochemical modulation of antimetabolites.
ISSN:	0008-5472 1538-7445