Exosomes in Angiogenesis and Anti-angiogenic Therapy in Cancers

Angiogenesis is the process through which new blood vessels are formed from pre-existing ones. Exosomes are involved in angiogenesis in cancer progression by transporting numerous pro-angiogenic biomolecules like vascular endothelial growth factor (VEGF), matrix metalloproteinases (MMPs), and microR...

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Veröffentlicht in:	International journal of molecular sciences 2020-08, Vol.21 (16), p.5840
Hauptverfasser:	Olejarz, Wioletta, Kubiak-Tomaszewska, Grażyna, Chrzanowska, Alicja, Lorenc, Tomasz
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Angiogenesis inhibitors Angiogenesis Inhibitors - therapeutic use Animals anti-angiogenic therapy Antiangiogenic agents Antiangiogenics Bevacizumab Biomolecules Biosynthesis Blood vessels Cancer therapies Crosstalk Drug resistance Endothelial cells Endothelial Cells - metabolism Endothelial Cells - pathology Exosomes Exosomes - metabolism extracellular vesicles Growth factors Humans Hypoxia Hypoxia-inducible factor 1 Immune system Immunotherapy Matrix metalloproteinase Matrix metalloproteinases Mesenchyme Metastasis MicroRNAs miRNA Monoclonal antibodies Neoplasms - blood supply Neoplasms - drug therapy Neovascularization, Pathologic - drug therapy Physiology Proteins Randomized Controlled Trials as Topic Review Stem cells Targeted cancer therapy Tumors Vascular endothelial growth factor
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