Diagnostic Limitations in Congenital Zika Virus Infection

This is the first documented case of an infant with congenital Zika virus infection (ZVI) born in Ireland. A term infant was delivered with an antenatal diagnosis of severe microcephaly. First trimester bloods confirmed maternal ZVI and although the infant did not have Zika virus RNA or Zika-specifi...

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Veröffentlicht in:	Irish medical journal 2020-06, Vol.113 (6), p.101
Hauptverfasser:	Flanagan, M, Hughes, H, Forman, E B, O'Rourke, D, Paturi, B, Curley, A, Knowles, S J, De Gascun, C, Sweetman, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers - analysis Diffusion Magnetic Resonance Imaging Female Humans Immunoglobulin M - analysis Infant Infant, Newborn Ireland Maternal-Fetal Exchange Microcephaly - diagnosis Microcephaly - virology Placenta - metabolism Placenta - virology Pregnancy Pregnancy Complications, Infectious - diagnosis Pregnancy Complications, Infectious - virology Pregnancy Trimester, First Prenatal Diagnosis Prenatal Exposure Delayed Effects RNA, Viral - analysis Severity of Illness Index Zika Virus - genetics Zika Virus - immunology Zika Virus Infection - congenital Zika Virus Infection - diagnosis Zika Virus Infection - virology
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Zusammenfassung:	This is the first documented case of an infant with congenital Zika virus infection (ZVI) born in Ireland. A term infant was delivered with an antenatal diagnosis of severe microcephaly. First trimester bloods confirmed maternal ZVI and although the infant did not have Zika virus RNA or Zika-specific IgM in her blood or urine, she had multiple clinical features of congenital ZVI and Zika virus RNA was present in the placenta.
ISSN:	0332-3102