LncRNA DDX11-AS1: a novel oncogene in human cancer

Long noncoding RNA (lncRNA) is a newly identified type of noncoding RNA with a length of more than 200 nucleotides. The latest research shows that lncRNAs play important roles in the occurrence and development of human tumours by acting both as carcinogenic genes and as tumour suppressor genes. LncR...

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Veröffentlicht in:	Human cell : official journal of Human Cell Research Society 2020-10, Vol.33 (4), p.946-953
Hauptverfasser:	Feng, Yubin, Wu, Maomao, Hu, Shuang, Peng, Xiaoqing, Chen, Feihu
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - genetics Biomarkers, Tumor Biomedical and Life Sciences Cancer Carcinogenesis - genetics Carcinogenicity Cell Biology Cell migration Cell Proliferation - genetics Colorectal carcinoma DEAD-box RNA Helicases - genetics DEAD-box RNA Helicases - physiology DNA Helicases - genetics DNA Helicases - physiology Gastric cancer Gene Expression Regulation, Neoplastic - genetics Genes, Tumor Suppressor Gynecology Hepatocellular carcinoma Humans Life Sciences Life Sciences & Biomedicine Molecular Targeted Therapy Neoplasm Invasiveness - genetics Neoplasms - diagnosis Neoplasms - drug therapy Neoplasms - genetics Neoplasms - pathology Non-small cell lung carcinoma Nucleotides Oncogenes Oncology Osteosarcoma Prognosis Reproductive Medicine Review Article Ribonucleic acid RNA RNA, Long Noncoding - genetics RNA, Long Noncoding - physiology Science & Technology Stem Cells Surgery Tumor suppressor genes Tumors
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Zusammenfassung:	Long noncoding RNA (lncRNA) is a newly identified type of noncoding RNA with a length of more than 200 nucleotides. The latest research shows that lncRNAs play important roles in the occurrence and development of human tumours by acting both as carcinogenic genes and as tumour suppressor genes. LncRNAs plays a role in various biological processes, such as cell growth, apoptosis, migration and invasion. The newly discovered lncRNA DDX11-AS1 is abnormally highly expressed in various malignant tumours, such as hepatocellular carcinoma, colorectal cancer, osteosarcoma, bladder cancer, NSCLC and gastric cancer. DDX11-AS1 mainly regulates the expression of related genes through direct or indirect ways to perform its functions in carcinogenicity. These results indicate that DDX11-AS1 may be a marker or therapeutic target of tumours. This review summarizes the biological function and mechanism of DDX11-AS1 in the process of tumour development.
ISSN:	0914-7470 1749-0774 1749-0774
DOI:	10.1007/s13577-020-00409-8