AIE based GSH activatable photosensitizer for imaging-guided photodynamic therapy

A novel ferrocene decorated vinyl pyridinium-substituted tetraphenylethylene ( TPEPY-S-Fc ) linked by a disulfide bond was designed as a GSH activatable photosensitizer by aggregation-induced emission for imaging-guided photodynamic therapy of cancer cells. A GSH activatable photosensitizer with agg...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2020-09, Vol.56 (71), p.1317-132
Hauptverfasser:	Zhang, You-Hui, Li, Xue, Huang, Li, Kim, Hyeong Seok, An, Jusung, Lan, Minhuan, Cao, Qian-Yong, Kim, Jong Seung
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Disulfides - chemistry Fluorescent Dyes - chemistry Fluorescent Dyes - pharmacology Glutathione - metabolism Humans Medical imaging Molecular Imaging NMR Nuclear magnetic resonance Photochemotherapy Photodynamic therapy Photosensitizing Agents - chemistry Photosensitizing Agents - pharmacology Stilbenes - chemistry Stilbenes - pharmacology
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Beschreibung
Zusammenfassung:	A novel ferrocene decorated vinyl pyridinium-substituted tetraphenylethylene ( TPEPY-S-Fc ) linked by a disulfide bond was designed as a GSH activatable photosensitizer by aggregation-induced emission for imaging-guided photodynamic therapy of cancer cells. A GSH activatable photosensitizer with aggregation-induced emission characteristics for imaging-guided photodynamic therapy of cancer cells.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/d0cc02045a