Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates

Two injections of an mRNA-based vaccine encoding the SARS-CoV-2 spike protein elicited high levels of neutralizing antibody and Th1 CD4 T-cell responses in rhesus macaques. Two days after challenge of vaccinated animals with intranasal and intratracheal virus, viral replication was undetectable in b...

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Veröffentlicht in:	The New England journal of medicine 2020-10, Vol.383 (16), p.1544-1555
Hauptverfasser:	Corbett, Kizzmekia S, Flynn, Barbara, Foulds, Kathryn E, Francica, Joseph R, Boyoglu-Barnum, Seyhan, Werner, Anne P, Flach, Britta, O’Connell, Sarah, Bock, Kevin W, Minai, Mahnaz, Nagata, Bianca M, Andersen, Hanne, Martinez, David R, Noe, Amy T, Douek, Naomi, Donaldson, Mitzi M, Nji, Nadesh N, Alvarado, Gabriela S, Edwards, Darin K, Flebbe, Dillon R, Lamb, Evan, Doria-Rose, Nicole A, Lin, Bob C, Louder, Mark K, O’Dell, Sijy, Schmidt, Stephen D, Phung, Emily, Chang, Lauren A, Yap, Christina, Todd, John-Paul M, Pessaint, Laurent, Van Ry, Alex, Browne, Shanai, Greenhouse, Jack, Putman-Taylor, Tammy, Strasbaugh, Amanda, Campbell, Tracey-Ann, Cook, Anthony, Dodson, Alan, Steingrebe, Katelyn, Shi, Wei, Zhang, Yi, Abiona, Olubukola M, Wang, Lingshu, Pegu, Amarendra, Yang, Eun Sung, Leung, Kwanyee, Zhou, Tongqing, Teng, I-Ting, Widge, Alicia, Gordon, Ingelise, Novik, Laura, Gillespie, Rebecca A, Loomis, Rebecca J, Moliva, Juan I, Stewart-Jones, Guillaume, Himansu, Sunny, Kong, Wing-Pui, Nason, Martha C, Morabito, Kaitlyn M, Ruckwardt, Tracy J, Ledgerwood, Julie E, Gaudinski, Martin R, Kwong, Peter D, Mascola, John R, Carfi, Andrea, Lewis, Mark G, Baric, Ralph S, McDermott, Adrian, Moore, Ian N, Sullivan, Nancy J, Roederer, Mario, Seder, Robert A, Graham, Barney S
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveoli Animals Antibodies, Neutralizing - blood Antibodies, Viral - blood Betacoronavirus - immunology Betacoronavirus - physiology Bronchus CD4 antigen CD4 Antigens CD8 antigen Coronaviridae Coronavirus Infections - immunology Coronavirus Infections - pathology Coronavirus Infections - prevention & control Coronavirus Infections - therapy Coronaviruses COVID-19 COVID-19 Vaccines Disease Models, Animal Dose-Response Relationship, Immunologic General & Internal Medicine Genomes Immunization Immunization, Passive Life Sciences & Biomedicine Lung - pathology Lung - virology Lymphocytes T Macaca mulatta Medicine, General & Internal mRNA Original Pandemics - prevention & control Pneumonia, Viral - immunology Pneumonia, Viral - pathology Pneumonia, Viral - prevention & control Pneumonia, Viral - therapy Polymerase chain reaction Primates Replication SARS-CoV-2 Science & Technology Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus Spike protein T-Lymphocytes - immunology Vaccines Viral Load Viral Vaccines - administration & dosage Viral Vaccines - immunology Virus Replication
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Beschreibung
Zusammenfassung:	Two injections of an mRNA-based vaccine encoding the SARS-CoV-2 spike protein elicited high levels of neutralizing antibody and Th1 CD4 T-cell responses in rhesus macaques. Two days after challenge of vaccinated animals with intranasal and intratracheal virus, viral replication was undetectable in bronchoalveolar-lavage fluid and nasal secretions.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2024671