Histone deacetylase inhibition promotes regenerative neurogenesis after stab wound injury in the adult zebrafish optic tectum

The central nervous system (CNS) of adult zebrafish is capable of recovering from injury, unlike the CNS of mammals such as humans or rodents. Previously, we established a stab wound injury model of the optic tectum (OT) in the adult zebrafish and showed that the radial glial cells (RG) proliferatio...

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Veröffentlicht in:	Biochemical and biophysical research communications 2020-08, Vol.529 (2), p.366-371
Hauptverfasser:	Kiyooka, Mariko, Shimizu, Yuki, Ohshima, Toshio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry & Molecular Biology Biophysics Brain regeneration Cell Proliferation - drug effects Female Histone deacetylase Histone Deacetylase Inhibitors - pharmacology Histone Deacetylase Inhibitors - therapeutic use Hydroxamic Acids - pharmacology Hydroxamic Acids - therapeutic use Life Sciences & Biomedicine Male Nerve Regeneration - drug effects Neurogenesis - drug effects Optic tectum Radial glial cell Science & Technology Stab wound injury Superior Colliculi - drug effects Superior Colliculi - injuries Superior Colliculi - physiology Superior Colliculi - physiopathology Wounds, Stab - drug therapy Wounds, Stab - physiopathology Zebrafish Zebrafish - physiology
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