Urine S-Adenosylmethionine are Related to Degree of Renal Insufficiency in Patients with Chronic Kidney Disease

Abstract Objective To determine whether urine S-adenosylmethionine (SAM) might be an indicator of chronic kidney disease (CKD). Methods We investigated urine levels of SAM and related metabolites (S-adenosylhomocysteine and homocysteine cysteine) in 62 patients (average age, 65.9 years) with CKD (st...

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Veröffentlicht in:	Laboratory medicine 2021-01, Vol.52 (1), p.47-56
Hauptverfasser:	Kruglova, Maria Petrovna, Ivanov, Alexander Vladimirovich, Virus, Edward Danielevich, Bulgakova, Polina Olegovna, Samokhin, Andrey Segeevich, Fedoseev, Anatolij Nikolaevich, Grachev, Sergej Vital’evich, Kubatiev, Aslan Amirkhanovich
Format:	Artikel
Sprache:	eng
Schlagworte:	Care and treatment Chronic kidney failure Comparative analysis Cysteine Homocysteine Kidney diseases Life Sciences & Biomedicine Medical Laboratory Technology Metabolites S-adenosylmethionine Science & Technology Type 2 diabetes Urine
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Zusammenfassung:	Abstract Objective To determine whether urine S-adenosylmethionine (SAM) might be an indicator of chronic kidney disease (CKD). Methods We investigated urine levels of SAM and related metabolites (S-adenosylhomocysteine and homocysteine cysteine) in 62 patients (average age, 65.9 years) with CKD (stages II–V). Results Patients with stages III–V CKD stages have significantly decreased urine levels and SAM/S-adenosylhomocysteine ratio and also cysteine/homocysteine ratio in blood plasma (P
ISSN:	0007-5027 1943-7730
DOI:	10.1093/labmed/lmaa034