Remaining kidney volume indexed to weight as a strong predictor of estimated glomerular filtration rate at 1 year and mid‐term renal function after living‐donor nephrectomy ‐ a retrospective observational study

The donors’ estimated glomerular filtration rate (eGFR) after living nephrectomy has been a concern, particularly in donors with smaller kindeys. Therefore, we developed this retrospective observational study in 195 donors to determine the ability remaining kidney volume indexed to weight (RKV/W) to...

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Veröffentlicht in:Transplant international 2020-10, Vol.33 (10), p.1262-1273
Hauptverfasser: Nunes‐Carneiro, Diogo, Madanelo, Mariana, Silva, Filipa, Pestana, Nicole, Ribeiro, Catarina, Gil‐Sousa, Diogo, Martins, La Salete, Almeida, Manuela, Dias, Leonídio, Malheiro, Jorge, Cavadas, Vítor, Castro‐Henriques, Antonio, Fraga, Avelino, Silva‐Ramos, Miguel
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Sprache:eng
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Zusammenfassung:The donors’ estimated glomerular filtration rate (eGFR) after living nephrectomy has been a concern, particularly in donors with smaller kindeys. Therefore, we developed this retrospective observational study in 195 donors to determine the ability remaining kidney volume indexed to weight (RKV/W) to predict eGFR at 1 year through multivariate linear regression and to explore this relationship between annual eGFR change from 1 to 4 years postdonation evaluated by a linear mixed model. Comparing RKV/W tertiles (T1, T2, T3), RKV/W was a good predictor of 1‐year eGFR which was significantly better in T3 donors. Gender, predonation eGFR, and RKV/W were independent predictors of eGFR at 1‐year. In a subgroup with predonation eGFR 
ISSN:0934-0874
1432-2277
DOI:10.1111/tri.13683