Intact HIV reservoir estimated by the intact proviral DNA assay correlates with levels of total and integrated DNA in the blood during suppressive antiretroviral therapy

Intact HIV reservoir estimated by the intact proviral DNA assay correlates with levels of total and integrated DNA in the blood during suppressive antiretroviral therapy

Accurate characterization of the HIV reservoir is imperative to develop an effective cure. HIV was measured in antiretroviral therapy-suppressed individuals using the intact proviral DNA assay (IPDA), along with assays for total or integrated HIV DNA, and inducible HIV RNA or p24. Intact provirus co...

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Veröffentlicht in:Clinical infectious diseases 2020-06
Hauptverfasser: Papasavvas, Emmanouil, Azzoni, Livio, Ross, Brian N, Fair, Matthew, Yuan, Zhe, Gyampoh, Kwasi, Mackiewicz, Agnieszka, Sciorillo, Amanda C, Paggliuzza, Amelie, Lada, Steven M, Wu, Guoxin, Goh, Shih Lin, Bahnck-Teets, Carolyn, Holder, Daniel J, Zuck, Paul D, Damra, Mohammad, Lynn, Kenneth M, Tebas, Pablo, Mounzer, Karam, Kostman, Jay R, Abdel-Mohsen, Mohamed, Richman, Douglas, Chomont, Nicolas, Howell, Bonnie J, Montaner, Luis J
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Sprache:eng
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Zusammenfassung:Accurate characterization of the HIV reservoir is imperative to develop an effective cure. HIV was measured in antiretroviral therapy-suppressed individuals using the intact proviral DNA assay (IPDA), along with assays for total or integrated HIV DNA, and inducible HIV RNA or p24. Intact provirus correlated with total and integrated HIV.
ISSN:1537-6591