The Protective Function of PRMT1 in Alcohol‐Induced Hepatocellular Carcinoma

According to the World Health Organization, more than 1 million patients are projected to die from liver cancer by 2030. The subsequent studies revealed increased inflammatory markers, including a higher number of macrophages, chemokines and cytokines, as well as increased iNOS and reactive nitrogen species in PRMT1hep/ than WT mice. [...]PRMT1hep/ mice exhibited more severe liver injury and hepatocyte death due to the impaired expression of antioxidants, such as Sod1 and Sod2 proteins. [...]the manuscript by Zhao et al. describes a function of PRMT1 in inhibiting HCC development caused by chronic alcohol consumption.