Trace analysis of bisphenol A and its analogues in eggs by ultra-performance liquid chromatography-tandem mass spectrometry

•A UPLC-MS/MS method was developed for bisphenols detection with LOD as low as 0.02 µg kg−1.•Validation of the method for determination of bisphenols contamination in real egg samples.•BPA was the most abundant contaminant (37.5%) with concentration levels at 0.28–1.05 μg kg−1.•Over ten-folds higher BPP contamination levels compared to BPA were found in two eggs. Presence of bisphenol A (BPA) and its analogues in various environmental matrices have been well studied by now, but there is still an insufficient data on the occurrence of BPA analogues in animal-derived foodstuffs. Hence, this work describes a quick, sensitive and reliable analytical method for the simultaneous determination of eight BPA analogues in eggs, applying a solid-phase extraction procedure with PRiME HLB cartridges that combines isolation of the analytes from matrix and the sample clean-up on a single column. The limits of detection (LODs) and quantification (LOQs) for BPA analogues were in the ranges of 0.02–0.05 μg kg−1 and 0.1–0.2 μg kg−1, respectively. Average recoveries were ranged between 82.7% and 105.2%. Quantitative analysis was performed on 24 real samples, the results indicate that low levels of BPA, BPB and BPS were detected, and interestingly, over ten folds higher BPP contamination levels compared to BPA were found in two egg samples.