Development of new self-assembled cationic amino liposomes for efficient gene delivery

A library of 83 structurally diverse cationic amino liposomes is rationally designed and parallelly synthesized for the transfection of plasmid DNA and siRNA. Our designed self-assembled liposomes not only exhibit excellent transfection efficiency in HEK 293T cells and mouse embryonic stem cells, bu...

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Veröffentlicht in:	Biomaterials science 2020-06, Vol.8 (11), p.321-325
Hauptverfasser:	Wu, Yihang, Xiong, Yue, Wang, Ling, Zhou, Quanming, Li, Linxian, Levkin, Pavel A, Davidson, Gary, Gao, Liqian, Deng, Wenbin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cations Cell Line Cell Survival DNA - administration & dosage Fibroblasts - metabolism Gene Transfer Techniques Humans Liposomes Materials Science Materials Science, Biomaterials Mice Mouse Embryonic Stem Cells - metabolism Plasmids RNA, Small Interfering - administration & dosage Science & Technology Self-assembly Stem cells Technology Toxicity
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Beschreibung
Zusammenfassung:	A library of 83 structurally diverse cationic amino liposomes is rationally designed and parallelly synthesized for the transfection of plasmid DNA and siRNA. Our designed self-assembled liposomes not only exhibit excellent transfection efficiency in HEK 293T cells and mouse embryonic stem cells, but also show low cytotoxicity. A library of lipidoids self-assembling to liposomes exhibits excellent transfection efficiency in HEK 293T cells and mESCs with low cytotoxicity.
ISSN:	2047-4830 2047-4849
DOI:	10.1039/d0bm00331j