High-glucose mixed nutrient meal ingestion impairs skeletal muscle microvascular blood flow in healthy young males
Oral glucose ingestion leads to impaired muscle microvascular blood flow (MBF) which likely contributes to acute hyperglycemia-induced insulin resistance. We investigated whether incorporating lipids and protein into a high-glucose load could prevent postprandial MBF dysfunction. Ten healthy young m...
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Veröffentlicht in: | American journal of physiology: endocrinology and metabolism 2020-04 |
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Sprache: | eng |
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Zusammenfassung: | Oral glucose ingestion leads to impaired muscle microvascular blood flow (MBF) which likely contributes to acute hyperglycemia-induced insulin resistance. We investigated whether incorporating lipids and protein into a high-glucose load could prevent postprandial MBF dysfunction.
Ten healthy young males (age: mean 27 years old, 95% lower and upper confidence interval [24, 30]; height: 180 cm [174, 185]; weight: 77 kg [70, 84]) ingested a high-glucose (1.1 g/kg glucose) mixed nutrient meal (10 kcal.kg
; 45% carbohydrate, 20% protein, and 35% fat) in the morning after an overnight fast. Femoral arterial blood flow was measured via Doppler ultrasound and thigh MBF was measured via contrast enhanced ultrasound prior to meal ingestion, and 1 hour and 2 hours postprandial. Blood glucose and plasma insulin were measured at baseline and every 15 minutes throughout the 2 hour postprandial period.
Compared to baseline, thigh muscle microvascular blood volume, velocity and flow were significantly impaired at 60 minutes postprandial (-25%, -27%, -46%, respectively; all p < 0.05) and to a greater extent at 120 minutes postprandial (-37%, -46%, -64%; all p < 0.01). Heart rate and femoral arterial diameter, blood velocity and flow, were significantly increased at 60 minutes and 120 minutes postprandial (all p < 0.05). Higher blood glucose area under the curve was correlated with greater MBF dysfunction (R
= 0.742; p < 0.001).
Ingestion of a high-glucose meal, despite the inclusion of lipids and protein, impairs MBF in healthy individuals for up to 2 hours postprandial. |
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ISSN: | 1522-1555 |
DOI: | 10.1152/ajpendo.00540.2019 |