Hierarchical binding of copper II to N-truncated Aβ 4-16 peptide
N-Truncated Aβ displays a high binding affinity with Cu . A mechanistic scheme of the interactions between Aβ and Cu has been proposed using a fluorescence approach. The timescales of different conversion steps were determined. This kinetic mechanism indicates the potential synaptic functions of Aβ...
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| Veröffentlicht in: | Metallomics 2020-04, Vol.12 (4), p.470 |
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| container_issue | 4 |
| container_start_page | 470 |
| container_title | Metallomics |
| container_volume | 12 |
| creator | Teng, Xiangyu Stefaniak, Ewelina Girvan, Paul Kotuniak, Radosław Płonka, Dawid Bal, Wojciech Ying, Liming |
| description | N-Truncated Aβ
displays a high binding affinity with Cu
. A mechanistic scheme of the interactions between Aβ
and Cu
has been proposed using a fluorescence approach. The timescales of different conversion steps were determined. This kinetic mechanism indicates the potential synaptic functions of Aβ
during neurotransmission. |
| doi_str_mv | 10.1039/c9mt00299e |
| format | Article |
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| fulltext | fulltext |
| identifier | EISSN: 1756-591X |
| ispartof | Metallomics, 2020-04, Vol.12 (4), p.470 |
| issn | 1756-591X |
| language | eng |
| recordid | cdi_pubmed_primary_32236192 |
| source | Oxford University Press Journals All Titles (1996-Current) |
| title | Hierarchical binding of copper II to N-truncated Aβ 4-16 peptide |
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