Hierarchical binding of copper II to N-truncated Aβ 4-16 peptide

Hierarchical binding of copper II to N-truncated Aβ 4-16 peptide

N-Truncated Aβ displays a high binding affinity with Cu . A mechanistic scheme of the interactions between Aβ and Cu has been proposed using a fluorescence approach. The timescales of different conversion steps were determined. This kinetic mechanism indicates the potential synaptic functions of Aβ...

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Veröffentlicht in:Metallomics 2020-04, Vol.12 (4), p.470
Hauptverfasser: Teng, Xiangyu, Stefaniak, Ewelina, Girvan, Paul, Kotuniak, Radosław, Płonka, Dawid, Bal, Wojciech, Ying, Liming
Format: Artikel
Sprache:eng
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Zusammenfassung:N-Truncated Aβ displays a high binding affinity with Cu . A mechanistic scheme of the interactions between Aβ and Cu has been proposed using a fluorescence approach. The timescales of different conversion steps were determined. This kinetic mechanism indicates the potential synaptic functions of Aβ during neurotransmission.
ISSN:1756-591X
DOI:10.1039/c9mt00299e