A terbium() luminescent ATCUN-based peptide sensor for selective and reversible detection of copper() in biological media

A terbium() luminescent ATCUN-based peptide sensor for selective and reversible detection of copper() in biological media

The measurement of exchangeable Cu 2+ levels in biological samples is gaining interest in the context of copper-related pathologies. Here, we report a Tb 3+ luminescent turn-off sensor for Cu 2+ based on the specific and suitable-affinity Xxx-Zzz-His (ATCUN) peptide motif, enabling Cu 2+ detection i...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2020-04, Vol.56 (35), p.4797-48
Hauptverfasser: Falcone, Enrico, Gonzalez, Paulina, Lorusso, Lucie, Sénèque, Olivier, Faller, Peter, Raibaut, Laurent
Format: Artikel
Sprache:eng
Schlagworte:
Biological properties
Chemical Sciences
Coordination chemistry
Copper
Copper compounds
Fluorescence
Peptides
Terbium
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Beschreibung
Zusammenfassung:The measurement of exchangeable Cu 2+ levels in biological samples is gaining interest in the context of copper-related pathologies. Here, we report a Tb 3+ luminescent turn-off sensor for Cu 2+ based on the specific and suitable-affinity Xxx-Zzz-His (ATCUN) peptide motif, enabling Cu 2+ detection in the presence of a biological fluorescent background. Detection of copper( ii ) in biological media via time-delayed luminescence by a selective and reversible terbium( iii )-luminescent peptide sensor with pM affinity.
ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc01007c