Sporormielones A-E, bioactive novel C-C coupled orsellinic acid derivative dimers, and their biosynthetic origin

Sporormielones A-E ( 1-5 ), novel C-C coupled orsellinic acid derivative dimers containing tricyclic cores with a dimethylcyclopentenone unit, were obtained, of which 1-3 and 5 showed obvious short-term memory improvement activity in AD flies. Based on transcriptome analysis, 13 C labelling, and gene deletion, their plausible biosynthetic mechanism was proposed. Sporormielones A-E, novel C-C coupled orsellinic acid derivative dimers containing tricyclic cores with a dimethylcyclopentenone unit, were isolated from Sporormiella sp., and their plausible biosynthetic mechanism was proposed.