Clinical features of dermatomyositis associated with anti-MDA5 antibodies by age

Anti-melanoma differentiation-associated gene 5 (MDA5) autoantibody-positive and age at onset ≥60 years are poor prognosis factors in polymyositis (PM) and dermatomyositis (DM) associated with interstitial lung disease (ILD) among Japanese patients. However, the influence of age on the clinical feat...

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Veröffentlicht in:	Modern rheumatology 2021, Vol.31 (1), p.177-185
Hauptverfasser:	Yamaguchi, Koichi, Yamaguchi, Aya, Onuki, Yuji, Itai, Miki, Kashiwagi, Chiharu, Takehara, Kazutaka, Aoki, Shuhei, Kanaya, Azusa, Taguchi, Kohei, Umetsu, Kazue, Oshima, Kazuma, Uchida, Megumi, Kimura, Hayato, Kasahara, Morimitsu, Takemura, Masao, Hara, Kenichiro, Sekiguchi, Akiko, Motegi, Sei-ichiro, Muro, Yoshinao, Nakasatomi, Masao, Motohashi, Rena, Sakairi, Toru, Nakagawa, Junichi, Hiromura, Keiju, Obokata, Masaru, Kurabayashi, Masahiko, Maeno, Toshitaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Factors Aged Anti-MDA5 autoantibody Autoantibodies - immunology Dermatomyositis - drug therapy Dermatomyositis - epidemiology Dermatomyositis - immunology Dermatomyositis - pathology Female Humans Immunosuppressive Agents - therapeutic use Interferon-Induced Helicase, IFIH1 - immunology Life Sciences & Biomedicine Male Middle Aged Mortality myositis-associated antibody older people rapidly progressive interstitial lung disease Rheumatology Science & Technology
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Zusammenfassung:	Anti-melanoma differentiation-associated gene 5 (MDA5) autoantibody-positive and age at onset ≥60 years are poor prognosis factors in polymyositis (PM) and dermatomyositis (DM) associated with interstitial lung disease (ILD) among Japanese patients. However, the influence of age on the clinical features of anti-MDA5 autoantibody-positive patients with DM remains unclear. We retrospectively examined 40 patients with DM and anti-MDA5 autoantibodies according to age. We compared patients aged
ISSN:	1439-7595 1439-7609
DOI:	10.1080/14397595.2020.1740400