A new rat model of treatment-naive quiescent choroidal neovascularization induced by human VEGF165 overexpression

Vascular endothelial growth factor (VEGF) is a crucial stimulator for choroidal neovascularization (CNV). Our aim was to develop a reproducible and valid treatment-naive quiescent CNV (i.e. without signs of exudation and with normal visual acuity) rat model by subretinal injection of an adeno-associ...

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Veröffentlicht in:	Biology open 2020-06, Vol.9 (6)
Hauptverfasser:	Liu, Shan, Biesemeier, Antje K, Tschulakow, Alexander V, Thakkar, Harsh V, Julien-Schraermeyer, Sylvie, Schraermeyer, Ulrich
Format:	Artikel
Sprache:	eng
Schlagworte:	Acuity Age Age related diseases age-related macular degeneration (amd) angiogenesis Animals Animals, Genetically Modified Basement membranes Bevacizumab choroidal neovascularization (cnv) Choroidal Neovascularization - diagnosis Choroidal Neovascularization - genetics Choroidal Neovascularization - therapy Disease Models, Animal DNA Copy Number Variations Drug delivery Electron microscopy electron microscopy (em) Endothelial cells Epithelium Exudation Eye Eye diseases Female Fluorescein Fluorescein Angiography Gene Expression Growth factors Humans Immunohistochemistry In vivo methods and tests Macrophages Macular degeneration Microglia Monoclonal antibodies Multilayers Rats Retina Retinal pigment epithelium Retinal Pigment Epithelium - metabolism Retinal Pigment Epithelium - pathology Retinal Pigment Epithelium - ultrastructure Stimulators Tomography, Optical Coherence - methods Vascular endothelial growth factor vascular endothelial growth factor (vegf) Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism Vascularization Visual acuity
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