A Fast and Simple Method for the Determination of TBA in 18 F-Labeled Radiopharmaceuticals
A simple color spot test for determining the presence of residual tetrabutylammonium (TBA) in various F-radiopharmaceuticals is described. The test can be performed in less than five minutes. Iodoplatinate-saturated TLC plates are initially spotted with the F-radiopharmaceutical to be tested and TBA...
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| Veröffentlicht in: | Pharmaceuticals (Basel, Switzerland) Switzerland), 2020-02, Vol.13 (2) |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | A simple color spot test for determining the presence of residual tetrabutylammonium (TBA) in various
F-radiopharmaceuticals is described. The test can be performed in less than five minutes. Iodoplatinate-saturated TLC plates are initially spotted with the
F-radiopharmaceutical to be tested and TBA, then with deionized water or hydrogen peroxide (H
O
) solution, depending on if an antioxidant stabilizer is part of the pharmaceutical matrix. A distinct brown spot is visible at TBA concentrations of 50 µg/mL and up. |
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| ISSN: | 1424-8247 1424-8247 |
| DOI: | 10.3390/ph13020027 |