HIV MDR is still a relevant issue despite its dramatic drop over the years

Abstract Objectives To evaluate the prevalence and therapeutic relevance of drug resistance among isolates from ART-experienced HIV-1-infected patients over the past two decades in Italy. Methods Dynamics of resistance to one, two and three or more antiretroviral classes were evaluated from 1999–201...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of antimicrobial chemotherapy 2020-05, Vol.75 (5), p.1301-1310
Hauptverfasser:	Armenia, D, Di Carlo, D, Flandre, P, Bouba, Y, Borghi, V, Forbici, F, Bertoli, A, Gori, C, Fabeni, L, Gennari, W, Pinnetti, C, Mondi, A, Cicalini, S, Gagliardini, R, Vergori, A, Bellagamba, R, Malagnino, V, Montella, F, Colafigli, M, Latini, A, Marocco, R, Licthner, M, Andreoni, M, Mussini, C, Ceccherini-Silberstein, F, Antinori, A, Perno, C F, Santoro, M M
Format:	Artikel
Sprache:	eng
Schlagworte:	Human health and pathology Infectious Diseases Life Sciences Life Sciences & Biomedicine Microbiology Pharmaceutical sciences Pharmacology Pharmacology & Pharmacy Santé publique et épidémiologie Science & Technology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Abstract Objectives To evaluate the prevalence and therapeutic relevance of drug resistance among isolates from ART-experienced HIV-1-infected patients over the past two decades in Italy. Methods Dynamics of resistance to one, two and three or more antiretroviral classes were evaluated from 1999–2018. Virological success (VS) after the latest therapy switch was evaluated according to cumulative class resistance and cumulative genotypic susceptibility score (Stanford HIV_DB algorithm). Results Among 13 663 isolates (from 6739 patients), resistance to at least one drug class decreased sharply from 1999 to 2010 (≤2001, 84.6%; 2010, 43.6%; P
ISSN:	0305-7453 1460-2091
DOI:	10.1093/jac/dkz554