A novel near-infrared fluorescent probe for detection of early-stage Aβ protofibrils in Alzheimer's disease

Detection of Aβ protofibrils at the early stage of Alzheimer's disease was realized by a novel near-infrared probe ( DCM-AN ) based on dicyanomethylene-4 H -pyran. This probe exhibits high affinity towards Aβ protofibrils in vitro and in brain sections of transgenic mouse models for Alzheimer&#...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2020-02, Vol.56 (11), p.1625-1628
Hauptverfasser:	Lv, Guanglei, Sun, Anyang, Wang, Minqi, Wei, Peng, Li, Ruohan, Yi, Tao
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Naphthylamine - analogs & derivatives 2-Naphthylamine - chemical synthesis 2-Naphthylamine - toxicity Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Amyloid beta-Peptides - analysis Animals Brain - metabolism Brain - pathology Female Fluorescent Dyes - chemistry Fluorescent Dyes - toxicity Fluorescent indicators Image detection Limit of Detection Male Mice, Inbred C57BL Mice, Transgenic Molecular Docking Simulation Molecular Dynamics Simulation Nitriles - chemical synthesis Nitriles - chemistry Nitriles - toxicity Rodents Spectrometry, Fluorescence - methods
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Beschreibung
Zusammenfassung:	Detection of Aβ protofibrils at the early stage of Alzheimer's disease was realized by a novel near-infrared probe ( DCM-AN ) based on dicyanomethylene-4 H -pyran. This probe exhibits high affinity towards Aβ protofibrils in vitro and in brain sections of transgenic mouse models for Alzheimer's disease. Detection of Aβ protofibrils at the early stage of Alzheimer's disease was realized by a novel near-infrared probe ( DCM-AN ) based on dicyanomethylene-4 H -pyran.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c9cc09233a