Peptide-based short single β-strand mimics without hydrogen bonding or aggregation

Generation of short peptides with a single β-strand structure in solution is difficult. Herein, we design a new class of single β-strand peptidic mimics that are stable without self-aggregation in protic and non-protic solvents. Introduction of one present β-strand mimic can induce and propagate the β-strand structure for at least a penta-peptide sequence. Both ( R - and S -) enantiomers of the bridgehead-substituted β-proline analogue ( i.e. , 7-azabicyclo[2.2.1]heptane-2-carboxylic acid or Abh amino acid ( Abh-AA )) can work as a new scaffold for single β-strand enforcement and propagation.