Cell therapy in muscular disorders: the future lies in comparisons of progenitors

Cell therapy approaches dedicated to the treatment of dystrophinopathies and involving essentially myoblasts and mesoangioblasts have produced mitigated clinical results. If several types of alternative progenitors have been developed, no standardized comparison has been carried out yet to investiga...

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Veröffentlicht in:	M.S. Médecine sciences 2019-11, Vol.35 Hors série n° 2, p.7
Hauptverfasser:	Vilquin, Jean-Thomas, Braun, Serge
Format:	Artikel
Sprache:	fre
Schlagworte:	Animals Cell Differentiation Cell- and Tissue-Based Therapy - methods Cell- and Tissue-Based Therapy - trends Cells, Cultured Humans Muscle, Skeletal - cytology Muscle, Skeletal - physiology Muscular Diseases - therapy Myoblasts - physiology Physiology, Comparative - methods Physiology, Comparative - standards Physiology, Comparative - trends Reference Standards Regenerative Medicine - standards Regenerative Medicine - trends Stem Cells - classification Stem Cells - cytology Stem Cells - physiology
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Beschreibung
Zusammenfassung:	Cell therapy approaches dedicated to the treatment of dystrophinopathies and involving essentially myoblasts and mesoangioblasts have produced mitigated clinical results. If several types of alternative progenitors have been developed, no standardized comparison has been carried out yet to investigate their regenerative efficacy in vivo, at least at a local level. A comparative study has therefore been designed recently aiming at giving a new impetus to this therapeutic field.
ISSN:	1958-5381
DOI:	10.1051/medsci/2019188