MRI versus 18 F-FDG-PET/CT for detecting bone marrow involvement in multiple myeloma: diagnostic performance and clinical relevance
To compare the diagnostic performance of MRI and F-FDG-PET/CT in detecting bone marrow involvement (BMI) in patients with multiple myeloma (MM). This retrospective study was approved by our Institutional Review Board. Two radiologists and two nuclear medicine specialists independently and blindly re...
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| Veröffentlicht in: | European radiology 2020-04, Vol.30 (4), p.1927 |
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| creator | Lecouvet, Frédéric E Boyadzhiev, Dimitar Collette, Laurence Berckmans, Maude Michoux, Nicolas Triqueneaux, Perrine Pasoglou, Vassiliki Jamar, François Vekemans, Marie-Christiane |
| description | To compare the diagnostic performance of MRI and
F-FDG-PET/CT in detecting bone marrow involvement (BMI) in patients with multiple myeloma (MM).
This retrospective study was approved by our Institutional Review Board. Two radiologists and two nuclear medicine specialists independently and blindly reviewed 84 pairs of MRI and PET/CT scans obtained in 73 MM patients. Readers assessed the presence and patterns of BMI. The best valuable comparator (BVC) for BMI was established by a panel review of all baseline and follow-up imaging, and biological and pathological information. Intra- and inter-reader agreement and correlation between MRI and PET/CT were assessed using the prevalence-adjusted bias-adjusted kappa (k) coefficient. Diagnostic performance of MRI and PET/CT in detecting BMI was evaluated from ROC characteristics. Association between imaging and biological, pathological, and clinical findings was assessed using Wilcoxon rank-sum and chi-square tests.
Intra- and inter-reader agreement was very good for MRI (k = 0.90 [0.81; 1.00] and 0.88 [0.78; 0.98]). Intra- and inter-reader agreement was good for PET/CT (k = 0.80 [0.69; 0.91] and 0.71 [0.56; 0.86]). The sensitivity of MRI to detect BMI (97% [90%; 100%]) was significantly superior to that of PET/CT (76% [64%; 85%]) (p |
| doi_str_mv | 10.1007/s00330-019-06469-1 |
| format | Article |
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F-FDG-PET/CT in detecting bone marrow involvement (BMI) in patients with multiple myeloma (MM).
This retrospective study was approved by our Institutional Review Board. Two radiologists and two nuclear medicine specialists independently and blindly reviewed 84 pairs of MRI and PET/CT scans obtained in 73 MM patients. Readers assessed the presence and patterns of BMI. The best valuable comparator (BVC) for BMI was established by a panel review of all baseline and follow-up imaging, and biological and pathological information. Intra- and inter-reader agreement and correlation between MRI and PET/CT were assessed using the prevalence-adjusted bias-adjusted kappa (k) coefficient. Diagnostic performance of MRI and PET/CT in detecting BMI was evaluated from ROC characteristics. Association between imaging and biological, pathological, and clinical findings was assessed using Wilcoxon rank-sum and chi-square tests.
Intra- and inter-reader agreement was very good for MRI (k = 0.90 [0.81; 1.00] and 0.88 [0.78; 0.98]). Intra- and inter-reader agreement was good for PET/CT (k = 0.80 [0.69; 0.91] and 0.71 [0.56; 0.86]). The sensitivity of MRI to detect BMI (97% [90%; 100%]) was significantly superior to that of PET/CT (76% [64%; 85%]) (p < 0.001). The specificity of MRI (86% [57%; 98%]) was lower than that of PET/CT (93% [66%; 100%]), without reaching statistical significance (p = 0.32). There was a strong correlation between decisions regarding patient management and PET/CT findings (p < 0.001).
MRI is significantly more sensitive than PET/CT to detect BMI in MM. Patient management is more strongly correlated with PET/CT findings.
• MRI and PET/CT have very close diagnostic value for the detection of bone marrow involvement in multiple myeloma. • MRI has a significantly higher sensitivity and better reproducibility. • PET/CT findings appear to have a higher impact on clinical decisions.</description><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-019-06469-1</identifier><identifier>PMID: 31844960</identifier><language>eng</language><publisher>Germany</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Bone Marrow - diagnostic imaging ; Bone Neoplasms - diagnosis ; Female ; Fluorodeoxyglucose F18 - pharmacology ; Humans ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; Multiple Myeloma - diagnosis ; Positron Emission Tomography Computed Tomography - methods ; Radiopharmaceuticals - pharmacology ; Reproducibility of Results ; Retrospective Studies</subject><ispartof>European radiology, 2020-04, Vol.30 (4), p.1927</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0003-3568-3254</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27915,27916</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31844960$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lecouvet, Frédéric E</creatorcontrib><creatorcontrib>Boyadzhiev, Dimitar</creatorcontrib><creatorcontrib>Collette, Laurence</creatorcontrib><creatorcontrib>Berckmans, Maude</creatorcontrib><creatorcontrib>Michoux, Nicolas</creatorcontrib><creatorcontrib>Triqueneaux, Perrine</creatorcontrib><creatorcontrib>Pasoglou, Vassiliki</creatorcontrib><creatorcontrib>Jamar, François</creatorcontrib><creatorcontrib>Vekemans, Marie-Christiane</creatorcontrib><title>MRI versus 18 F-FDG-PET/CT for detecting bone marrow involvement in multiple myeloma: diagnostic performance and clinical relevance</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><description>To compare the diagnostic performance of MRI and
F-FDG-PET/CT in detecting bone marrow involvement (BMI) in patients with multiple myeloma (MM).
This retrospective study was approved by our Institutional Review Board. Two radiologists and two nuclear medicine specialists independently and blindly reviewed 84 pairs of MRI and PET/CT scans obtained in 73 MM patients. Readers assessed the presence and patterns of BMI. The best valuable comparator (BVC) for BMI was established by a panel review of all baseline and follow-up imaging, and biological and pathological information. Intra- and inter-reader agreement and correlation between MRI and PET/CT were assessed using the prevalence-adjusted bias-adjusted kappa (k) coefficient. Diagnostic performance of MRI and PET/CT in detecting BMI was evaluated from ROC characteristics. Association between imaging and biological, pathological, and clinical findings was assessed using Wilcoxon rank-sum and chi-square tests.
Intra- and inter-reader agreement was very good for MRI (k = 0.90 [0.81; 1.00] and 0.88 [0.78; 0.98]). Intra- and inter-reader agreement was good for PET/CT (k = 0.80 [0.69; 0.91] and 0.71 [0.56; 0.86]). The sensitivity of MRI to detect BMI (97% [90%; 100%]) was significantly superior to that of PET/CT (76% [64%; 85%]) (p < 0.001). The specificity of MRI (86% [57%; 98%]) was lower than that of PET/CT (93% [66%; 100%]), without reaching statistical significance (p = 0.32). There was a strong correlation between decisions regarding patient management and PET/CT findings (p < 0.001).
MRI is significantly more sensitive than PET/CT to detect BMI in MM. Patient management is more strongly correlated with PET/CT findings.
• MRI and PET/CT have very close diagnostic value for the detection of bone marrow involvement in multiple myeloma. • MRI has a significantly higher sensitivity and better reproducibility. • PET/CT findings appear to have a higher impact on clinical decisions.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bone Marrow - diagnostic imaging</subject><subject>Bone Neoplasms - diagnosis</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18 - pharmacology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multiple Myeloma - diagnosis</subject><subject>Positron Emission Tomography Computed Tomography - methods</subject><subject>Radiopharmaceuticals - pharmacology</subject><subject>Reproducibility of Results</subject><subject>Retrospective Studies</subject><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFTs1OwzAYi5AQG4MX4IC-Fwj7QqOu5TpWxgEJTb1PWfptCspPlaRFO_PiFAnOnGzZlm3G7gQ-CMTVMiEWBXIUNcdSljUXF2wuZPHIBVZyxq5T-kDEWsjVFZsVopKyLnHOvt52rzBSTEMCUUHDm-cX_r5pl-sWjiFCR5l0Nv4Eh-AJnIoxfILxY7AjOfJ54uAGm01vJ_tMNjj1BJ1RJx9SNhp6ilORU14TKN-BtsYbrSxEsjT-yDfs8qhsottfXLD7ZtOut7wfDo66fR_NtHve_70u_g18A2gQU3U</recordid><startdate>202004</startdate><enddate>202004</enddate><creator>Lecouvet, Frédéric E</creator><creator>Boyadzhiev, Dimitar</creator><creator>Collette, Laurence</creator><creator>Berckmans, Maude</creator><creator>Michoux, Nicolas</creator><creator>Triqueneaux, Perrine</creator><creator>Pasoglou, Vassiliki</creator><creator>Jamar, François</creator><creator>Vekemans, Marie-Christiane</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><orcidid>https://orcid.org/0000-0003-3568-3254</orcidid></search><sort><creationdate>202004</creationdate><title>MRI versus 18 F-FDG-PET/CT for detecting bone marrow involvement in multiple myeloma: diagnostic performance and clinical relevance</title><author>Lecouvet, Frédéric E ; Boyadzhiev, Dimitar ; Collette, Laurence ; Berckmans, Maude ; Michoux, Nicolas ; Triqueneaux, Perrine ; Pasoglou, Vassiliki ; Jamar, François ; Vekemans, Marie-Christiane</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_318449603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Bone Marrow - diagnostic imaging</topic><topic>Bone Neoplasms - diagnosis</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18 - pharmacology</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multiple Myeloma - diagnosis</topic><topic>Positron Emission Tomography Computed Tomography - methods</topic><topic>Radiopharmaceuticals - pharmacology</topic><topic>Reproducibility of Results</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lecouvet, Frédéric E</creatorcontrib><creatorcontrib>Boyadzhiev, Dimitar</creatorcontrib><creatorcontrib>Collette, Laurence</creatorcontrib><creatorcontrib>Berckmans, Maude</creatorcontrib><creatorcontrib>Michoux, Nicolas</creatorcontrib><creatorcontrib>Triqueneaux, Perrine</creatorcontrib><creatorcontrib>Pasoglou, Vassiliki</creatorcontrib><creatorcontrib>Jamar, François</creatorcontrib><creatorcontrib>Vekemans, Marie-Christiane</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lecouvet, Frédéric E</au><au>Boyadzhiev, Dimitar</au><au>Collette, Laurence</au><au>Berckmans, Maude</au><au>Michoux, Nicolas</au><au>Triqueneaux, Perrine</au><au>Pasoglou, Vassiliki</au><au>Jamar, François</au><au>Vekemans, Marie-Christiane</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MRI versus 18 F-FDG-PET/CT for detecting bone marrow involvement in multiple myeloma: diagnostic performance and clinical relevance</atitle><jtitle>European radiology</jtitle><addtitle>Eur Radiol</addtitle><date>2020-04</date><risdate>2020</risdate><volume>30</volume><issue>4</issue><spage>1927</spage><pages>1927-</pages><eissn>1432-1084</eissn><abstract>To compare the diagnostic performance of MRI and
F-FDG-PET/CT in detecting bone marrow involvement (BMI) in patients with multiple myeloma (MM).
This retrospective study was approved by our Institutional Review Board. Two radiologists and two nuclear medicine specialists independently and blindly reviewed 84 pairs of MRI and PET/CT scans obtained in 73 MM patients. Readers assessed the presence and patterns of BMI. The best valuable comparator (BVC) for BMI was established by a panel review of all baseline and follow-up imaging, and biological and pathological information. Intra- and inter-reader agreement and correlation between MRI and PET/CT were assessed using the prevalence-adjusted bias-adjusted kappa (k) coefficient. Diagnostic performance of MRI and PET/CT in detecting BMI was evaluated from ROC characteristics. Association between imaging and biological, pathological, and clinical findings was assessed using Wilcoxon rank-sum and chi-square tests.
Intra- and inter-reader agreement was very good for MRI (k = 0.90 [0.81; 1.00] and 0.88 [0.78; 0.98]). Intra- and inter-reader agreement was good for PET/CT (k = 0.80 [0.69; 0.91] and 0.71 [0.56; 0.86]). The sensitivity of MRI to detect BMI (97% [90%; 100%]) was significantly superior to that of PET/CT (76% [64%; 85%]) (p < 0.001). The specificity of MRI (86% [57%; 98%]) was lower than that of PET/CT (93% [66%; 100%]), without reaching statistical significance (p = 0.32). There was a strong correlation between decisions regarding patient management and PET/CT findings (p < 0.001).
MRI is significantly more sensitive than PET/CT to detect BMI in MM. Patient management is more strongly correlated with PET/CT findings.
• MRI and PET/CT have very close diagnostic value for the detection of bone marrow involvement in multiple myeloma. • MRI has a significantly higher sensitivity and better reproducibility. • PET/CT findings appear to have a higher impact on clinical decisions.</abstract><cop>Germany</cop><pmid>31844960</pmid><doi>10.1007/s00330-019-06469-1</doi><orcidid>https://orcid.org/0000-0003-3568-3254</orcidid></addata></record> |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Aged Aged, 80 and over Bone Marrow - diagnostic imaging Bone Neoplasms - diagnosis Female Fluorodeoxyglucose F18 - pharmacology Humans Magnetic Resonance Imaging - methods Male Middle Aged Multiple Myeloma - diagnosis Positron Emission Tomography Computed Tomography - methods Radiopharmaceuticals - pharmacology Reproducibility of Results Retrospective Studies |
| title | MRI versus 18 F-FDG-PET/CT for detecting bone marrow involvement in multiple myeloma: diagnostic performance and clinical relevance |
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