Ruthenium-catalyzed meta-C-H bond alkylation of aryl 2-pyridyl ketones

Ruthenium-catalyzed meta-C-H bond alkylation of aryl 2-pyridyl ketones

The first example of meta-selective CAr-H bond functionalization of aryl 2-pyridyl ketones has been developed using [Ru(p-cymene)Cl2]2 as the catalyst and alkyl bromide as the coupling reagent. This development provides an efficient strategy for modifying the meta-position of aryl 2-pyridyl ketone s...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2020-01, Vol.56 (2), p.293-296
Hauptverfasser: Li, Gang, Jia, Chunqi, Cai, Xiaofeng, Zhong, Lei, Zou, Lei, Cui, Xiuling
Format: Artikel
Sprache:eng
Schlagworte:
Alkylation
Aromatic compounds
Coupling (molecular)
Hydrogen bonds
Ketones
Reagents
Ruthenium
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Zusammenfassung:The first example of meta-selective CAr-H bond functionalization of aryl 2-pyridyl ketones has been developed using [Ru(p-cymene)Cl2]2 as the catalyst and alkyl bromide as the coupling reagent. This development provides an efficient strategy for modifying the meta-position of aryl 2-pyridyl ketone skeletons, which are found in various functional molecules.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc08624b