Anaphylactic shock-induced conditioned taste aversion: I. Demonstration of the phenomenon by means of three modes of CS-US presentation
A series of three experiments was conducted to investigate whether an anaphylactic response could induce a conditioned modification of behavior. Rats sensitized to ovalbumin were subjected to a conditioning trial in which the conditioned stimulus (CS; saccharin solution) signaled the presentation of...
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Veröffentlicht in: | Brain, behavior, and immunity behavior, and immunity, 1988, Vol.2 (1), p.11-23 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | A series of three experiments was conducted to investigate whether an anaphylactic response could induce a conditioned modification of behavior. Rats sensitized to ovalbumin were subjected to a conditioning trial in which the conditioned stimulus (CS; saccharin solution) signaled the presentation of the unconditioned stimulus (US; shocking dose of ovalbumin), eliciting the unconditioned response (UR; anaphylactic shock). In a subsequent two-bottle preference test, immunized rats given a CS-US pairing developed a conditioned taste aversion toward an otherwise preferred saccharin solution. The phenomenon of anaphylactic shock-induced conditioned taste aversion was found to be robust and resistant to extinction during the 6-day test period and was established employing three modes of CS-US presentation: (a) CS po, US ip; (b) CS po, US iv; and (c) CS iv, US iv. The most effective mode of CS-US presentation for producing anaphylactic shock-induced taste aversion was observed in Experiment 1 (CS po, US ip). Thus, aversive manifestations of anaphylactic shock can serve as afferent signals by which the immune system informs the central nervous system which in turn modulates behavior. |
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ISSN: | 0889-1591 1090-2139 |
DOI: | 10.1016/0889-1591(88)90002-5 |