Severity of Hypertension Mediates the Association of Hyperuricemia With Stroke in the REGARDS Case Cohort Study

Severity of Hypertension Mediates the Association of Hyperuricemia With Stroke in the REGARDS Case Cohort Study

Previous studies do not widely support hyperuricemia as a risk factor for stroke and other cardiovascular diseases. We assessed the relationship between hyperuricemia and ischemic stroke (≈900 cases) using a large data set from the REGARDS study (Reasons for Geographic and Racial Differences in Stro...

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Veröffentlicht in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2020-01, Vol.75 (1), p.246-256
Hauptverfasser: Chaudhary, Ninad S., Bridges, S. Louis, Saag, Kenneth G., Rahn, Elizabeth J., Curtis, Jeffrey R., Gaffo, Angelo, Limdi, Nita A., Levitan, Emily B., Singh, Jasvinder A., Colantonio, Lisandro D., Howard, George, Cushman, Mary, Flaherty, Matthew L., Judd, Suzanne, Irvin, Marguerite R., Reynolds, Richard J.
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Blood Pressure - physiology
Cardiovascular System & Cardiology
Cohort Studies
Female
Humans
Hypertension - complications
Hypertension - diagnosis
Hypertension - physiopathology
Hyperuricemia - blood
Hyperuricemia - complications
Hyperuricemia - physiopathology
Life Sciences & Biomedicine
Male
Middle Aged
Peripheral Vascular Disease
Risk Factors
Science & Technology
Severity of Illness Index
Stroke - blood
Stroke - complications
Stroke - physiopathology
Uric Acid - blood
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Zusammenfassung:Previous studies do not widely support hyperuricemia as a risk factor for stroke and other cardiovascular diseases. We assessed the relationship between hyperuricemia and ischemic stroke (≈900 cases) using a large data set from the REGARDS study (Reasons for Geographic and Racial Differences in Stroke). We employed a case-cohort design (incident stroke cases and randomly selected cohort participants) and weighted Cox-proportional hazard models to estimate the association of serum urate level ≥6.8 mg/dL (ie, hyperuricemia) and 6.0 to
ISSN:0194-911X
1524-4563
DOI:10.1161/HYPERTENSIONAHA.119.13580