Aggregation-induced emission-active Au nanoclusters for ratiometric sensing and bioimaging of highly reactive oxygen species

We prepared a nanoprobe through self-assembly of gold nanoclusters (AuNCs) and using FITC-modified hyaluronic acid (HA) for ratiometric sensing of highly reactive oxygen species (hROS). Taking advantage of the aggregation-induced emission (AIE) properties of the self-assembled AuNCs, hROS-responsive...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2019-12, Vol.55 (1), p.1597-151
Hauptverfasser:	Ran, Xiang, Wang, Zhenzhen, Pu, Fang, Liu, Zhen, Ren, Jinsong, Qu, Xiaogang
Format:	Artikel
Sprache:	eng
Schlagworte:	Agglomeration Animals Emission Glutathione - chemistry Gold - chemistry Hyaluronic acid Lipopolysaccharides - pharmacology Macrophages - cytology Macrophages - enzymology Macrophages - metabolism Medical imaging Metal Nanoparticles - chemistry Metal Nanoparticles - toxicity Mice Microscopy, Fluorescence Nanoclusters RAW 264.7 Cells Reactive Oxygen Species - analysis Self-assembly Spectrometry, Fluorescence - methods
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Beschreibung
Zusammenfassung:	We prepared a nanoprobe through self-assembly of gold nanoclusters (AuNCs) and using FITC-modified hyaluronic acid (HA) for ratiometric sensing of highly reactive oxygen species (hROS). Taking advantage of the aggregation-induced emission (AIE) properties of the self-assembled AuNCs, hROS-responsive cleavage of HA, and the ratiometric signal change of dual-emission, the nanoprobe exhibited excellent performance in imaging hROS in living cells. A nanoprobe based on aggregation-induced emission-active Au nanoclusters for ratiometric sensing and bioimaging of highly reactive oxygen species is constructed.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c9cc08170d