Elevated Hs-CRP Levels Are Associated with Higher Risk of Intracranial Arterial Stenosis

Correlation between the level of high-sensitivity C-reactive protein (hs-CRP) and the incidence of intracranial arterial stenosis (ICAS) is unclear. We aim to investigate the relationship between hs-CRP levels and ICAS. A total of 1458 patients aged ≥ 40 years were enrolled in this study. All the pa...

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Veröffentlicht in:	Neurotoxicity research 2020-02, Vol.37 (2), p.425-432
Hauptverfasser:	Su, Bing-Jie, Dong, Yi, Tan, Chen-Chen, Hou, Xiao-He, Xu, Wei, Sun, Fu-Rong, Cui, Mei, Dong, Qiang, Tan, Lan, Yu, Jin-Tai
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biomarkers - blood Biomedical and Life Sciences Biomedicine C-Reactive Protein - metabolism Cell Biology Cerebrovascular Disorders - blood Cerebrovascular Disorders - diagnostic imaging Female Humans Magnetic Resonance Angiography - methods Male Middle Aged Neurobiology Neurochemistry Neurology Neurosciences Original Article Pharmacology/Toxicology Prospective Studies Stroke - blood Stroke - diagnostic imaging
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Zusammenfassung:	Correlation between the level of high-sensitivity C-reactive protein (hs-CRP) and the incidence of intracranial arterial stenosis (ICAS) is unclear. We aim to investigate the relationship between hs-CRP levels and ICAS. A total of 1458 patients aged ≥ 40 years were enrolled in this study. All the participants had a magnetic resonance angiography (MRA) examination for the evaluation of ICAS. Participants were classified into four groups according to stroke and ICAS. Multivariable logistic regression models were used to assess the relationship of hs-CRP levels and ICAS status. A total of 432 (29.63%) subjects had ICAS. The levels of hs-CRP in stroke group were significantly higher than those in non-stroke group ( p
ISSN:	1029-8428 1476-3524
DOI:	10.1007/s12640-019-00108-9