Antithrombin supplementation in adult patients receiving extracorporeal membrane oxygenation

Introduction: Extracorporeal membrane oxygenation is associated with an increased risk of thrombosis and hemorrhage. Acquired antithrombin deficiency often occurs in patients receiving extracorporeal membrane oxygenation, necessitating supplementation to restore adequate anticoagulation. Criteria fo...

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Veröffentlicht in:	Perfusion 2020-01, Vol.35 (1), p.66-72
Hauptverfasser:	Morrisette, Matthew J, Zomp-Wiebe, Amanda, Bidwell, Katherine L, Dunn, Steven P, Gelvin, Michael G, Money, Dustin T, Palkimas, Surabhi
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticoagulants Antithrombin Bleeding Cardiac & Cardiovascular Systems Cardiovascular System & Cardiology Evaluation Extracorporeal membrane oxygenation Hemorrhage Heparin Hernias Levels Life Sciences & Biomedicine Membranes Oxygenation Peripheral Vascular Disease Platelets Respiratory therapy Science & Technology Statistical analysis Supplements Thromboembolism Thrombosis
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Zusammenfassung:	Introduction: Extracorporeal membrane oxygenation is associated with an increased risk of thrombosis and hemorrhage. Acquired antithrombin deficiency often occurs in patients receiving extracorporeal membrane oxygenation, necessitating supplementation to restore adequate anticoagulation. Criteria for antithrombin supplementation in adult extracorporeal membrane oxygenation patients are not well defined. Methods: In this retrospective observational study, adult patients receiving antithrombin supplementation while supported on extracorporeal membrane oxygenation were evaluated. Antithrombin was supplemented when anti-Xa levels were subtherapeutic with unfractionated heparin infusion rates of 15-20 units/kg/h and measured antithrombin activity
ISSN:	0267-6591 1477-111X
DOI:	10.1177/0267659119856229