Exploration of the Product of the 5-Point Investigator’s Global Assessment and Body Surface Area (IGA × BSA) as a Practical Minimal Disease Activity Goal in Patients with Moderate-to-Severe Psoriasis

Background/Aims: In the treat-to-target era, psoriasis disease activity measures that can be easily performed in routine clinical practice are needed. This retrospective pooled analysis explored cutoff values of the product of the 5-point Investigator’s Global Assessment and percentage of affected b...

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Veröffentlicht in:Dermatology (Basel) 2019-01, Vol.235 (4), p.348-354
Hauptverfasser: Gottlieb, Alice B., Germino, Rebecca, Herrera, Vivian, Meng, Xiangyi, Merola, Joseph F.
Format: Artikel
Sprache:eng
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Zusammenfassung:Background/Aims: In the treat-to-target era, psoriasis disease activity measures that can be easily performed in routine clinical practice are needed. This retrospective pooled analysis explored cutoff values of the product of the 5-point Investigator’s Global Assessment and percentage of affected body surface area (IGA × BSA) correlating with achievement of minimal disease activity (MDA). Methods: Post hoc analysis of the phase 3 clinical trials ERASURE, FIXTURE, FEATURE, and JUNCTURE was conducted to determine associations between IGA × BSA and 2 MDA definitions (Psoriasis Area and Severity Index [PASI] 90 and Dermatology Life Quality Index [DLQI] 0/1, or PASI score ≤1 or BSA
ISSN:1018-8665
1421-9832
DOI:10.1159/000499925