A spermine-conjugated lipophilic Pt() prodrug designed to eliminate cancer stem cells in ovarian cancer

We developed a spermine-conjugated lipophilic Pt( iv ) prodrug that is able to reduce the cancer stem cell population in ovarian cancer. The therapeutic effect is attributed to the hydrophobic tail and cationic spermine head group, the combination of which allows the Pt( iv ) prodrug to localize in...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2019-05, Vol.55 (43), p.616-619
Hauptverfasser:	Stilgenbauer, Morgan, Jayawardhana, Amarasooriya M. D. S, Datta, Payel, Yue, Zhizhou, Gray, Michael, Nielsen, Frederick, Bowers, David J, Xiao, Haihua, Zheng, Yao-Rong
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Cell Line, Tumor Female Flow Cytometry Humans Hydrophobic and Hydrophilic Interactions Neoplastic Stem Cells - drug effects Ovarian Neoplasms - pathology Platinum Compounds - pharmacology Prodrugs - chemistry Prodrugs - pharmacology Spectrophotometry, Atomic Spermine - chemistry Spermine - pharmacology
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Beschreibung
Zusammenfassung:	We developed a spermine-conjugated lipophilic Pt( iv ) prodrug that is able to reduce the cancer stem cell population in ovarian cancer. The therapeutic effect is attributed to the hydrophobic tail and cationic spermine head group, the combination of which allows the Pt( iv ) prodrug to localize in mitochondria and induce corresponding damage. A spermine-conjugated lipophilic Pt( iv ) prodrug is designed to induce mitochondrial damage and eliminate ovarian cancer stem cells.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c9cc02081k