Size-controlled synthesis of polymerized DNA nanoparticles for targeted anticancer drug delivery

Size-controlled synthesis of polymerized DNA nanoparticles for targeted anticancer drug delivery

We synthesized size-tunable polymerized DNA nanoparticles (PDNs) for cancer-targeted drug delivery via sequential processes of rolling circle amplification, condensation, and layer-by-layer assembly. The PDNs selectively delivered anti-sense oligonucleotides to target cancer cells and exhibited size...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2019-04, Vol.55 (34), p.495-498
Hauptverfasser: Nam, Keonwook, Kim, Taehyung, Kim, Young Min, Yang, Kyungjik, Choe, Deokyoung, Mensah, Lawrence B, Choi, Ki Young, Roh, Young Hoon
Format: Artikel
Sprache:eng
Schlagworte:
Cancer
Chemical synthesis
Deoxyribonucleic acid
DNA
Drug delivery systems
Gene expression
Nanoparticles
Oligonucleotides
Polymerization
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Zusammenfassung:We synthesized size-tunable polymerized DNA nanoparticles (PDNs) for cancer-targeted drug delivery via sequential processes of rolling circle amplification, condensation, and layer-by-layer assembly. The PDNs selectively delivered anti-sense oligonucleotides to target cancer cells and exhibited size-dependent gene regulation efficacy. The size-tunable polymerized DNA nanoparticles (PDNs) for cancer-targeted drug delivery were synthesized via sequential processes of rolling circle amplification, condensation, and layer-by-layer assembly.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc01442j