THE CLINICAL RESULT OF RENAL TRANSPLANTATION: 100 Times in 97 Cases

The clinical result was studied in 56 living and 44 cadaveric renal transplantations including 4 regraftings at our department during the period from November, 1979 to August, 1987. In living renal transplantation, the 1-year survival rate of grafts receiving steroid, cyclosporin (Cs) and preoperative lymphocytapheresis (LA) was 93.9%. On the other hand, the 1-year graft survival rate of cases treated with steroid and azathioprine (Az-patients) and that of receiving steroid, mizoribine (Mz) and LA were 55.6% and 79.2%, respectively. The graft survival rate of Cs and LA-treated patients was significantly higher than that of Az-patients. In cadaveric renal transplantation, the 1-year survival rates of patients and grafts receiving steroid and Cs {Cs(+)} were 100% and 72.6%, respectively. Those of non-receiving Cs {Cs(-)} were 63.0% and 49.0%, respectively. The survival rates of patients between Cs(+) and Cs(-) were significantly different. As regards post-operative serious complications, a significant decrease of liver dysfunction and a significant increase of ATN were observed in Cs(+). Bacterial pulmonary infection, leucopenia and aseptic necrosis of the head of the femur tended to be decreased in Cs(+). Although the frequency of acute rejection episodes showed no difference between Cs(+) and Cs(-), many rejection episodes in Cs(+) were milder than those in Cs(+). Also, cytomegalovirus infection decreased in Cs(+). Csnephrotoxicity was observed in 47.8% of living transplants and 47.1% of cadaveric grafts.